MRP1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | MRP1, Human |
| Clone | REA481 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:10 |
| Applications | Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | MRP1 Antibody, anti-human, PE, REAfinity™. Clone REA481 recognizes an intracellular epitope of the human multidrug resistance-associated protein 1 (MRP1) antigen, a 190 kDa multi-pass membrane protein also known as ATP-binding cassette sub-family C member 1 (ABCC1) or leukotriene C(4) transporter. MRP1 was initially identified because of its ability to confer multidrug resistance in lung cancer cells. It plays a role in protecting certain tissues from xenobiotic insults and that it mediates the ATP-dependent transport of glutathione and glutathione conjugates, leukotriene C4, estradiol-17-beta-o-glucuronide, methotrexate, antiviral drugs, and other xenobiotics from the cytoplasm. MRP1 also plays a role in the cellular efflux of the reduced and oxidized forms of glutathione and thus contributes to the many physiological and pathophysiological processes influenced by these small peptides, including oxidative stress. | Additional information: Clone REA481 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | ABCC1, ABC29, ABCC, GS-X, MRP, MRP-1 |
| Gene, Accession # | Gene ID: 4363 |
| Catalog # | 130-107-467 |
| Price | $315 |
| Order / More Info | MRP1, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Cole, S. P. et al. (1992) Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line. Science 258 (5088): 1650-1654. | He, S. M. et al. (2011) Structural and functional properties of human multidrug resistance protein 1 (MRP1/ABCC1). Curr. Med. Chem. 18 (3): 439-481. | Leslie, E. M. et al. (2005) Multidrug resistance proteins: role of P-glycoprotein, MRP1, MRP2, and BCRP (ABCG2) in tissue defense. Toxicol. Appl. Pharmacol. 204 (3): 216-237. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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