CD122 (IL-2Rβ), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD122 (IL-2Rβ), Human |
| Clone | REA167 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | PE-Vio 615 conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD122 (IL-2Rβ) Antibody, anti-human, PE-Vio® 615, REAfinity™. Clone REA167 recognizes CD122, the 75 KDa β subunit of the high and intermediate affinity interleukin 2 receptor (IL-2R). CD122 is a type I transmembrane protein, and together with α subunit (CD25) or with α and γ (CD132) subunit, it forms the heteromeric intermediate and high affinity IL-2 receptors, respectively. In addition, CD122 is also a component of the IL-15 receptor complex. Expression of CD122 is found constitutively in CD8 cytotoxic T cells but not in CD4 T? cells and is further induced upon T cell activation. CD16+ NK lymphocytes also express CD122 constitutively. CD122 is essential for IL-2 signaling. | Additional information: Clone REA167 displays negligible binding to Fc receptors. ????? |
| Immunogen | n/a |
| Other Names | IL2RB, IL-15RB, P70-75 |
| Gene, Accession # | Gene ID: 3560 |
| Catalog # | 130-130-736 |
| Price | $166 |
| Order / More Info | CD122 (IL-2Rβ), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Gesbert, F. et al. (2005) IL-2 responsiveness of CD4 and CD8 lymphocytes: further investigations with human IL-2Rβ transgenic mice. Int. Immunol. 17: 1093-1102. | Friedmann, M. C. et al. (1996) Different interleukin 2 receptor beta-chain tyrosines couple to at least two signaling pathways and synergistically mediate interleukin 2-induced proliferation. Proc. Natl. Acad. Sci. U.S.A. 93 (5): 2077-2082. | Migone, T. S. et al. (1998) Functional cooperation of the interleukin-2 receptor beta chain and Jak1 in phosphatidylinositol 3-kinase recruitment and phosphorylation. Mol. Cell. Biol. 18 (11): 6416-6422. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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