CD49a, Mouse/Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD49a, Mouse/Rat |
| Clone | REA493 |
| Host Species | Recombinant Human |
| Reactive Species | mouse, rat |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD49a Antibody, anti-mouse/rat, APC, REAfinity™. Clone REA493 recognizes the mouse and rat CD49a antigen, a 180 kDa single-pass type I membrane protein also known as integrin α1 (Itga1). CD49a binds to CD29 (integrin β1) to form the heterodimeric integrin very late antigen 1 (VLA-1), which has been found to be widely expressed on various cell types, including mesenchymal cells, epithelial cells, macrophages, NKT cells, and T cells. VLA-1 is a receptor for laminin and collagen and interacts, via the I-domain of the extracellular domain of the CD49a subunit, with collagen molecules in the extracellular matrix. CD49a expression parallels high levels of IFN-γ production in effector T cells, and CD49a has been intensively studied for its role in mediating T-cell accumulation, apoptosis, and retention within pathological tissues in immune-mediated inflammation. | Additional information: Clone REA493 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Itga1, VLA-1 |
| Gene, Accession # | Gene ID: 25118, 109700 |
| Catalog # | 130-127-870 |
| Price | $104 |
| Order / More Info | CD49a, Mouse/Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Ben-Horin, S. et al. (2004) The role of very late antigen-1 in immune-mediated inflammation. Clin. Immunol. 113 (2): 119-129. | Chen, Y. et al. (2014) CD49a promotes T-cell-mediated hepatitis by driving T helper 1 cytokine and interleukin-17 production. Immunology 141 (3): 388-400. | Gindraux, F. et al. (2007) Human and rodent bone marrow mesenchymal stem cells that express primitive stem cell markers can be directly enriched by using the CD49a molecule. Cell Tissue Res. 327 (3): 471-483. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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