CD209b (SIGN-R1), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD209b (SIGN-R1), Mouse |
| Clone | REA125 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD209b (SIGN-R1) Antibody, anti-mouse, PE-Vio® 770, REAfinity™. Clone REA125 recognizes the mouse CD209b antigen, a single-pass type II membrane protein also known as DC-SIGN-related protein 1 (SIGN-R1). CD209b was identified by examination of the mouse genome in search of the complete set of proteins related to the human glycan binding receptor CD209 (DC-SIGN). Unlike the human CD209, mouse CD209b is not expressed on dendritic cells (DCs) but is on splenic marginal zone, lymph node, and peritoneal macrophages. Its high affinity for murine ICAM-2, and its localization at sites that are in close contact with blood, suggest a role for CD209b in lymphocyte migration from the blood into tissues. Moreover, marginal zone macrophages in the spleen efficiently capture blood-borne antigens in vivo through CD209b. CD209b has also been shown to interact with the TLR signaling system, with CD209b associating with the TLR4-MD2 complex to enhance signal transduction in response to LPS in Gram-negative bacteria in vitro. | Additional information: Clone REA125 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | DC-SIGNR1, OtB7, SIGNR1, mSIGNR1 |
| Gene, Accession # | Gene ID: 69165 |
| Catalog # | 130-106-332 |
| Price | $156 |
| Order / More Info | CD209b (SIGN-R1), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Saunders, S. P. et al. (2001) C-type lectin SIGN-R1 has a role in experimental colitis and responsiveness to lipopolysaccharide. J Immunol 184 (5): 2627-2637. | Geijtenbeek, T. B. et al. (2002) Marginal zone macrophages express a murine homologue of DC-SIGN that captures blood-borne antigens in vivo. Blood 100 (8): 2908-2916. | Park, C. G. et al. (2001) Five mouse homologues of the human dendritic cell C-type lectin, DC-SIGN. Int. Immunol. 13 (10): 1283 -1290. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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