CD217 (IL-17RA), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD217 (IL-17RA), Human |
| Clone | REA290 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD217 (IL-17RA) Antibody, anti-human, PE-Vio® 770, REAfinity™. Clone REA290 recognizes the human CD217 antigen, a single-pass type I membrane protein which is also known as interleukin-17 receptor A (IL-17RA). CD217 is a ubiquitously expressed receptor and subsequently shown to bind interleukin 17 (IL-17) with high affinity. IL-17 is an inflammatory cytokine that acts as a potent mediator in delayed-type reactions by increasing chemokine production in various tissues to recruit monocytes and neutrophils to the site of inflammation. It also plays critical roles in the pathogenesis of multiple autoimmune diseases. CD217 forms heterodimeric complexes with several other members of its receptor family, including IL-17RC for IL-17A and IL-17F signaling and IL-17RC for IL-17E (IL-25) signaling. | Additional information: Clone REA290 displays negligible binding to Fc receptors | |
| Immunogen | n/a |
| Other Names | IL17RA, CANDF5, CDw217, IL-17RA, IL17R, hIL-17R |
| Gene, Accession # | Gene ID: 23765 |
| Catalog # | 130-104-770 |
| Price | $162 |
| Order / More Info | CD217 (IL-17RA), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Ding, Y. et al. (2013) IL-17RA is essential for optimal localization of follicular Th cells in the germinal center light zone to promote autoantibody-producing B cells. J Immunol 191 (4): 1614-1624. | Toy, D. et al. (2006) Cutting edge: interleukin 17 signals through a heteromeric receptor complex. J Immunol 177 (1): 36-39. | Yao, Z. et al. (1997) Molecular characterization of the human interleukin (IL)-17 receptor. Cytokine 9 (11): 794-800. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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