TNF-α, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | TNF-α, Mouse |
| Clone | REA636 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | fluorescein (FITC) conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TNF-α Antibody, anti-mouse, FITC, REAfinity™. Clone REA636 recognizes the mouse tumor necrosis factor α (TNF-α) antigen, a 17 kDa cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. TNF-α is produced by cells that are involved in inflammatory immune responses. It is secreted by activated CD4+ T cells, monocytes, macrophages, NK cells, and neutrophils. TNF-α binding to surface receptors elicits a wide array of biologic activities, including cytolysis and cytostasis of many tumor cell lines in vitro, hemorraghic necrosis of tumors in vivo, increased fibroblast proliferation, and enhanced chemotaxis and phagocytosis in neutrophils. Furthermore it causes fever by direct action or by stimulation of interleukin-1 secretion. | Additional information: Clone REA636 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | TNFa, TNFalpha, TNF-alpha, Cachectin, Tnfsf1a, TNFSF2 |
| Gene, Accession # | Gene ID: 21926 |
| Catalog # | 130-124-212 |
| Price | $53 |
| Order / More Info | TNF-α, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Chyuan, I. T. et al. (2015) Tumor necrosis factor-alpha blockage therapy impairs hepatitis B viral clearance and enhances T-cell exhaustion in a mouse model. Cell. Mol. Immunol. 12 (3): 317-325. | Torrente, Y. et al. (2003) Tumor necrosis factor-alpha (TNF-alpha) stimulates chemotactic response in mouse myogenic cells. Cell Transplant 12 (1): 91-100. | Kaiser, G. C. et al. (1997) Tumor necrosis factor alpha regulates proliferation in a mouse intestinal cell line. Gastroenterology 112 (4): 1231-1240. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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