Plexin-B2, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Plexin-B2, Human |
| Clone | REA626 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry, Immunocytochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Plexin-B2 Antibody, anti-human, APC, REAfinity™. Clone REA626 recognizes the human plexin-B2 antigen, a single-pass type I membrane protein, which belongs to the semaphorin receptor family, B subfamily. Plexin-B2 is expressed in the nervous system and on other cells including cells of the immune system. It is expressed on T cells and T cell-dependent germinal center B cells. Expression is also found on macrophages, conventional dendritic cells, and plasmacytoid dendritic cells. Plexin-B2 plays an important role in cell-cell signaling, axon guidance, invasive growth, and cell migration. It has several semaphorin ligands including semaphorin-3E, semaphorin-4A, semaphorin-4C, and semaphorin-4D (CD100). Binding to class 4 semaphorins promotes the downstream activation of RHOA and phosphorylation of ERBB2. During skin damage repairs, CD100 interacts with plexin-B2 on γδ T cells to play a role in the healing process. | Additional information: Clone REA626 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Plxnb2, MM1, Nbla00445, dJ402G11.3 |
| Gene, Accession # | Gene ID: 23654 |
| Catalog # | 130-109-772 |
| Price | $142 |
| Order / More Info | Plexin-B2, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Witherden, D. A. et al. (2012) The CD100 receptor interacts with its plexin B2 ligand to regulate epidermal γδ T cell function. Immunity 37 (2): 314-325. | Deng, S. et al. (2007) Plexin-B2, but not Plexin-B1, critically modulates neuronal migration and patterning of the developing nervous system in vivo. J. Neurosci. 27 (23): 6333-6347. | Le, A. P. et al. (2015) Plexin-B2 promotes invasive growth of malignant glioma. Oncotarget. 6 (9): 7293-7304. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
Profile of MILTENYI BIOTEC B.V. & Co. KG