ChemR23 (CMKLR1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | ChemR23 (CMKLR1), Human |
| Clone | REA455 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | ChemR23 (CMKLR1) Antibody, anti-human, PE, REAfinity™. Clone REA455 recognizes the human G-protein-coupled receptor ChemR23 antigen, a multi-pass membrane protein which is also known as chemokine-like receptor 1 (CMKLR1). ChemR23 is expressed by leukocyte populations such as macrophages, immature myeloid and plasmacytoid dendritic cells, as well as on a subset of natural killer (NK) cells. Its natural ligand, chemerin, is a small protein isolated and identified from human inflammatory fluids which acts as a chemoattractant agent for leukocytes expressing ChemR23. Activation of ChemR23 results in intracellular calcium release, inhibition of cAMP accumulation, and phosphorylation of ERK-1/ERK-2 MAP kinases. Chemerin and ChemR23 are involved in the recruitment of NK and dendritic cells (DCs) into tissues in several human inflammatory diseases. They also participate to the regulation of adipocyte metabolism. | Additional information: Clone REA455 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Cmklr1, CHEMERINR, Dez, RVER1 |
| Gene, Accession # | Gene ID: 1240 |
| Catalog # | 130-125-091 |
| Price | $315 |
| Order / More Info | ChemR23 (CMKLR1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Samson, M. et al. (1998) ChemR23, a putative chemoattractant receptor, is expressed in monocyte-derived dendritic cells and macrophages and is a coreceptor for SIV and some primary HIV-1 strains. Eur. J. Immunol. 28 (5): 1689-1700. | Methner, A. et al. (1997) A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development. Biochem. Biophys. Res. Commun. 233 (2): 336-342. | Bondue, B. et al. (2012) The chemerin/ChemR23 system does not affect the pro-inflammatory response of mouse and human macrophages ex vivo. PLoS One 7 (6): 400-443. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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