CD192 (CCR2), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD192 (CCR2), Mouse |
| Clone | REA538 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD192 (CCR2) Antibody, anti-mouse, Biotin, REAfinity™. Clone REA538 recognizes the mouse CD192 antigen, a multi-pass membrane protein, which is also known as C-C chemokine receptor type 2 (CCR2) or monocyte chemoattractant protein 1 receptor (MCP-1-R). CD192 is a receptor for the CCL2, CCL7, and CCL12 chemokines and plays important roles in the recruitment of monocytes, macrophages, and T cells. It transduces a signal by increasing intracellular calcium ion levels. In mice CD192 is homogeneously expressed on monocytes and on 2-15% of T cells, closely resembling the expression pattern in humans. The percentage of CD192+ T cells is almost two times higher in the T?1-prone mouse strain C57BL/6 than in the T?2-prone strain BALB/c. The strain-dependent expression correlates to a reduced T?1 response described in CD192-deficient mice. | Additional information: Clone REA538 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | CCR2, CC-CKR-2, CCR2B, Ckr2, CKR2A, Ckr2b, Cmkbr2, mJe-r, MCP-1-R |
| Gene, Accession # | Gene ID: 12772 |
| Catalog # | 130-128-939 |
| Price | $51 |
| Order / More Info | CD192 (CCR2), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Mack, M. et al. (2001) Expression and characterization of the chemokine receptors CCR2 and CCR5 in mice. J Immunol 166 (7): 4697-4704. | Majmudar, M. D. et al. (2013) Monocyte-directed RNAi targeting CCR2 improves infarct healing in atherosclerosis-prone mice. Circulation 127 (20): 2038-2046. | Kurihara, T. et al. (1996) Cloning and functional expression of mCCR2, a murine receptor for the C-C chemokines JE and FIC. J. Biol. Chem. 271 (20): 11603-11607. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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