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Antigenic Specificity | CD68, Human |
Clone | Y1/82A |
Host Species | Mouse |
Reactive Species | human, nonhuman primate |
Isotype | IgG2bκ |
Format | fluorescein (FITC) conjugate |
Size | 30 tests in 300 µL |
Concentration | 1:10 |
Applications | Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD68 Antibody, anti-human, FITC. The monoclonal antibody Y1/82A reacts with CD68, a 110 kDa type I transmembrane glycoprotein classified as a lysosomal/endosomal-associated membrane glycoprotein (LAMP) family member. CD68 is highly expressed by human monocytes and tissue macrophages but also found in subpopulations of B cells, fibroblasts, endothelial, and other cells. It is found predominantely in late endosomal and lysosomal compartments, with a modest level of cell surface expression. CD68 is suggested to be involved in phagocytic activities of tissue macrophages, in intracellular lysosomal metabolism, and extracellular cell-cell and cell-pathogen interactions. |
Immunogen | n/a |
Other Names | gp110, Lamp4, SCARD1, macrosialin |
Gene, Accession # | Gene ID: 968 |
Catalog # | 130-100-299 |
Price | $93 |
Order / More Info | CD68, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Holness, C. L. and Simmons, D. L. (1993) Molecular cloning of CD68, a human macrophage marker related to lysosomal glycoproteins. Blood 81: 1607-1613. | Kurushima, H. et al. (2000) Surface expression and rapid internalization of macrosialin (mouse CD68) on elicited mouse peritoneal macrophages. J. Leukoc. Biol. 67: 104-108. | Saito, N. et al. (1991) Ultrastructural localization of the CD68 macrophage-associated antigen in human blood neutrophils and monocytes. Am. J. Pathol. 139: 1053-1059. | Holness, C. L. et al. (1993) Macrosialin, a mouse macrophage-restricted glycoprotein, is a member of the lamp/lgp family. J. Biol. Chem. 268: 9661-9666. | Gottfried, L. A. et al. (2008) Expression of CD68 in non-myeloid cell types. Scand. J. Immunol. 67: 453-463. |