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Antigenic Specificity | CD338 (ABCG2), Human |
Clone | 5D3 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG2bκ |
Format | biotin conjugate |
Size | 100 tests in 1 mL |
Concentration | 1:11 |
Applications | Mass cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD338 (ABCG2) Antibody, anti-human, Biotin. Clone 5D3 recognizes the human CD338 antigen, a multi-pass membrane protein which is also known as ATP-binding cassette sub-family G member 2 (ABCG2) or breast cancer resistance protein (BCRP). CD338 is a member of the ATP-binding cassette transporter superfamily and is known to contribute to multidrug resistance in cancer chemotherapy. It is highly expressed on primitive stem cells as identified by the side-population phenotype, which is characterized by the efflux of chemicals, including the fluorescent dye Hoechst 33342 and Rhodamine 123. Among ABC transporters that are known to cause multidrug resistance, CD338 is particularly interesting for its potential role in protecting cancer stem cells and its complex oligomeric structure. |
Immunogen | n/a |
Other Names | ABCG2, Breast cancer resistance protein (BCRP, BCRP1), CDw338, Mitoxantrone resistance-associated protein (MXR), Placenta-specific ATP-binding cassette transporter, Urate exporter |
Gene, Accession # | Gene ID: 9429 |
Catalog # | 130-104-956 |
Price | $264 |
Order / More Info | CD338 (ABCG2), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Allikmets, R. et al. (1998) A human placenta-specific ATP-binding cassette gene (ABCP) on chromosome 4q22 that is involved in multi drug resistance. Cancer Res. 58 (23): 5337-5339. | Zhou, S. et al. (2001) The ABC transporter Bcrp1/ABCG2 is expressed in a wide variety of stem cells and is a molecular determinant of the side-population phenotype. Nat Med 7 (9): 1028-1034. | Mo, W. et al. (2012) Human ABCG2: structure, function, and its role in multi drug resistance. Int J Biochem Mol Biol 3 (1): 1-27. |