LAT pY226, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | LAT pY226, Human |
| Clone | REA146 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | LAT pY226 Antibody, anti-human, PE, REAfinity™. Clone REA146 recognizes LAT phosphorylated at tyrosine 226. Linker of T cell activation (LAT), a transmembrane adaptor molecule, is constitutively localized in the lipid rafts and is involved in transducing the signal initiated by triggered T cell receptor (TCR). Upon TCR engagement, SRC and SYK family of protein tyrosine kinases (PTKs) are activated and LAT is phosphorylated at multiple conserved tyrosine residues in its cytosolic domain by Syk-family PTK Zap-70. Phosphorylated LAT can associate with several downstream SH2 domain containing proteins such as GRB2, PLCy1, ITK, GADS, and p85 subunit of PI3K to propagate the TCR activation signal and to activate several downstream pathways. pY226 motif can be bound directly by GRB2, GADS, and PLC-y1. Expression of LAT is found in thymocytes, T cells, mast cells, natural killer (NK cells), and platelets. Thymocytes lacking LAT are completely blocked at the pro-T3 stage in thymopoiesis. | Additional information: Clone REA146 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | LAT1, pp36 |
| Gene, Accession # | Gene ID: 27040 |
| Catalog # | 130-100-064 |
| Price | $110 |
| Order / More Info | LAT pY226, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Finco, T. S. et al. (1998) LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. Immunity 9 (5): 617-626. | Zhang, W. et al. (1999) Essential role of LAT in T cell development. Immunity 10 (3): 323-332. | Zhang, W. et al. (1998) LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92 (1): 83-92. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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