Edit |   |
---|---|
Antigenic Specificity | COX-4, Human |
Clone | REAL694 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | n/a |
Format | phycoerythrin (PE) conjugate |
Size | 200 µL |
Concentration | n/a |
Applications | MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | COX-4 Antibody, anti-human, PE, REAdye_lease™. Clone REAL694 is an antibody fragment derived from the full COX-4 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity. | Clone REAL694 recognizes the human COX-4 protein, one of the nuclear-coded polypeptide chains of cytochrome c oxidase, the terminal oxidase in mitochondrial electron transport. COX-4 can be used to identify the inner membrane of mitochondria in immunfluorescence studies. Mutations in the gene have been associated with COX deficiency and Fanconi anemia. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). |
Immunogen | n/a |
Other Names | COX IV-1 (Cytochrome c oxidase subunit IV isoform 1), Cytochrome c oxidase subunit 4 isoform 1, Cytochrome c oxidase polypeptide IV, COX4, COX IV |
Gene, Accession # | n/a |
Catalog # | 130-126-578 |
Price | $470 |
Order / More Info | COX-4, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Bottinger, L. et al. (2013) A complex of Cox4 and mitochondrial Hsp70 plays an important role in the assembly of the cytochrome c oxidase. Mol. Biol. Cell 24 (17): 2609-2619. | Oliva, C. R. et al. (2015) Nuclear-encoded cytochrome c oxidase subunit 4 regulates BMI1 expression and determines proliferative capacity of high-grade gliomas. Oncotarget. 6 (6): 4330-4344. |