MLC2a, Human/Mouse/Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | MLC2a, Human/Mouse/Rat |
| Clone | REA398 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse, rat |
| Isotype | IgG1 |
| Format | VioBlue conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | MLC2a Antibody, anti-human/mouse/rat, VioBlue®, REAfinity™. Clone REA398 recognizes the human, mouse, and rat atrial isoform of the myosin light chain 2 (MLC2a) antigen. Myosin is a hexamer composed of two myosin heavy chains and four myosin light chains. In the heart two different forms of the myosin light chain are expressed, the atrial form (MLC2a) and the ventricular form (MLC2v). MLC2a is expressed at high levels in atrial cardiomyocytes while MLC2v is essentially restricted to ventricular cardiomyocytes, albeit low levels of both MLC2a and MLC2v persist in the inflow tract, the atrioventricular canal, and the outflow tract of the heart during cardiogenesis. MLC2a expression may as well be suitable to identify mouse and human pluripotent stem cell-derived cardiomyocyte subtypes. | Additional information: Clone REA398 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | MYL7, MYL2A, MYLC2A, MLC-2a |
| Gene, Accession # | Gene ID: 58498 |
| Catalog # | 130-125-531 |
| Price | $148 |
| Order / More Info | MLC2a, Human/Mouse/Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Nishigaki, R. et al. (2002) An extra human chromosome 21 reduces mlc-2a expression in chimeric mice and Down syndrome. Biochem. Biophys. Res. Commun. 295 (1): 112-118. | Hailstones, D. et al. (1992) Differential regulation of the atrial isoforms of the myosin light chains during striated muscle development. J. Biol. Chem. 267 (32): 23295-23300. | Bizy, A. et al. (2013) Myosin light chain 2-based selection of human iPSC-derived early ventricular cardiac myocytes. Stem Cell Res. 11 (3): 1335-1347. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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