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Antigenic Specificity | HLA-E, Human |
Clone | 3D12 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1κ |
Format | allophycocyanin (APC) conjugate |
Size | 30 tests in 60 µL |
Concentration | 1:50 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | HLA-E Antibody, anti-human, APC. The 3D12 monoclonal antibody recognizes the human HLA-E protein, a member of the human leukocyte antigen family. HLA-E is a non-classical MHC molecule (MHC-Ib) with limited polymorphisms, which is expressed on the cell surface in a heterodimeric complex with β2-microglobulin. HLA-E is ubiquitously expressed and has a specialized role in NK cell recognition. It binds a restricted set of peptides, e.g., derived from other class I leader sequences. The complex is recognized by NKG2A on NK cells. This recognition protects the HLA-E-expressing cell from NK cell killing. Recently HLA-E recognition by a specialised subset of CD8 T cells has been implicated in pathogen recognition as well as autoimmunity. |
Immunogen | n/a |
Other Names | QA1, EA1.2, EA2.1, HLA-6.2, MHC, HLA-E |
Gene, Accession # | Gene ID: 3133 |
Catalog # | 130-120-157 |
Price | $140 |
Order / More Info | HLA-E, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Pietra, G. et al. (2010) The emerging role of HLA-E-restricted CD8+ T lymphocytes in the adaptive immune response to pathogens and tumors. J. Biomed. Biotechnol.: 907092. | Lu, L. et al. (2008) Generation and regulation of CD8+ regulatory T cells. Cell. Mol. Immunol. 5 (6): 401-406. | Jiang, H. et al. (2010) HLA-E-restricted regulatory CD8+ T cells are involved in development and control of human autoimmune type 1 diabetes. J. Clin. Invest. 120 (10): 3641-3650. |