CD344 (Frizzled-4), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD344 (Frizzled-4), Human |
| Clone | CH3A4A7 |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG1κ |
| Format | PerCP-Vio 700 conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD344 (Frizzled-4) Antibody, anti-human, PerCP-Vio® 700. Clone CH3A4A7 recognizes an extracellular epitope of the human CD344 antigen, a multi-pass membrane protein which is also known as Frizzled family receptor 4 (FZD4) or Frizzled-4. CD344 is expressed by neuronal stem cells and also found on fetal neuronal progenitor cells and neuronal intestinal cells. It is a member of the Frizzled family of proteins which encode seven-transmembrane domain proteins that are receptors for the wingless-type MMTV integration site family of signaling proteins. CD344 is involved in the activation of Wnt/β-catenin pathway (canonic Wnt signaling). It is the only representative of frizzled family members that binds strongly an additional ligand norrin that is functionally similar but structurally different from wingless-type proteins. CD344 signaling induced by norrin regulates vascular development of vertebrate retina and controls important blood vessels in the ear. |
| Immunogen | n/a |
| Other Names | FZD4, EVR1, FEVR, FZD4S, Fz-4, Fz4, FzE4, GPCR, hFz4 |
| Gene, Accession # | Gene ID: 8322 |
| Catalog # | 130-106-616 |
| Price | $129 |
| Order / More Info | CD344 (Frizzled-4), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Kirikoshi, H. et al. (1999) Molecular cloning and characterization of human Frizzled-4 on chromosome 11q14-q21. Biochem. Biophys. Res. Commun. 264 (3): 955-961. | Ye, X. et al. (2009) Norrin, frizzled-4, and Lrp5 signaling in endothelial cells controls a genetic program for retinal vascularization. Cell 139 (2): 285-298. | Descamps, B. et al. (2012) Frizzled 4 regulates arterial network organization through noncanonical Wnt/planar cell polarity signaling. Circ. Res. 110 (1): 47-58. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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