CD39, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD39, Human |
| Clone | REAL785 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | n/a |
| Format | phycoerythrin (PE) conjugate |
| Size | 200 µL |
| Concentration | n/a |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD39 Antibody, anti-human, PE, REAdye_lease™. Clone REAL785 is an antibody fragment derived from the full CD39 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity. | Clone REAL785 recognizes the 70 to 100 kDa membrane-bound human CD39 molecule, which is expressed on an effector/memory-like subset of FoxP3+ regulatory T cells. CD39 is an ectonucleotidase and catalyzes the hydrolysis of extracellular nucleotides, for example, ATP. In concert with CD73, an ecto-5'-nucleotidase, this can lead to the production of adenosine. High extracellular ATP concentrations indicate tissue injury and cell death and induce various pro-inflammatory responses in immune cells. | Through its enzymatic activity, CD39 can contribute to the suppressive function of regulatory T cells, for example, by eliminating extracellular ATP or by generating adenosine, which has suppressive effects on various immune cells. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). |
| Immunogen | n/a |
| Other Names | Entpd1, ATPDase, NTPDase-1, SPG64, gp80 |
| Gene, Accession # | n/a |
| Catalog # | 130-125-078 |
| Price | $490 |
| Order / More Info | CD39, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Maliszewski, C. R. et al. (1994) The CD39 lymphoid cell activation antigen. Molecular cloning and structural characterization. J Immunol 153 (8): 3574-3583. | Borsellino, G. et al. (2007) Expression of ectonucleotidase CD39 by FoxP3+ reg cells: hydrolysis of extracellular ATP and immune suppression. Blood 110: 1225-1232. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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