CD371 (CLEC12A), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD371 (CLEC12A), Human |
| Clone | REA431 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:11 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD371 (CLEC12A) Antibody, anti-human, PE-Vio® 770, REAfinity™. Clone REA431 recognizes CD371, the human C-type lectin domain family 12 member A (CLEC12A) antigen, a single-pass type II membrane protein which is also known as C-type lectin-like molecule 1 (CLL-1), dendritic cell-associated lectin 2 (DCAL2), or myeloid inhibitory C-type lectin-like receptor (MICL). CD371 (CLEC12A) is a immunoreceptor tyrosine-based inhibitory motif (ITIM) containing C-type lectin receptor encoded within the dectin-1 cluster. This receptor binds unknown endogenous ligands and is widely expressed on innate immune cells, including neutrophils, monocytes, macrophages, and dendritic cells (DCs). There are conflicting data on its expression on human natural killer (NK) cells. Its intracellular ITIM sequence recruits the tyrosine phosphatases SHP-1 and SHP-2 to negatively regulate Syk signaling. Because the expression of CD371 (CLEC12A) can be downregulated under inflammatory conditions, this receptor might be involved in the control of myeloid cell activation. CD371 (CLEC12A) has been shown to enhance LPS responses and to induce expression of CCR7, a chemokine involved in DC migration. It has been proposed that signals from CD371 (CLEC12A) may synergize with signals from other receptors to facilitate DC responses such as migration and T cell stimulation. | Additional information: Clone REA431 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | MICL, CLL-1, DCAL-2 |
| Gene, Accession # | Gene ID: 160364 |
| Catalog # | 130-106-436 |
| Price | $350 |
| Order / More Info | CD371 (CLEC12A), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Lahoud, M. H. et al. (2009) The C-type lectin Clec12A present on mouse and human dendritic cells can serve as a target for antigen delivery and enhancement of antibody responses. J Immunol 182 (12): 7587-7594. | Neumann, K. et al. (2014) Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death. Immunity 40 (3): 389-399. | Bakker, A. B. et al. (2004) C-type lectin-like molecule-1: a novel myeloid cell surface marker associated with acute myeloid leukemia. Cancer Res. 64 (22): 8443-8450. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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