CCL4 (MIP-1β), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CCL4 (MIP-1β), Human |
| Clone | REA511 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio B515 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CCL4 (MIP-1β) Antibody, anti-human, Vio® B515, REAfinity™. Clone REA511 recognizes the human C-C motif chemokine 4 (CCL4) antigen, a secreted protein, which is also known as macrophage inflammatory protein 1 beta (MIP-1β). CCL4 is a chemoattractant for natural killer cells, monocytes, and a variety of other immune cells. It is expressed primarily by T cells, B cells, and monocytes after antigen or mitogen stimulation. The functional receptor for CCL4 beta has been identified as CCR5. CCL4 is a proinflammatory chemokine that both promotes leukocyte accumulation in various inflammatory conditions and contributes to protective immunity against human immunodeficiency virus type 1 (HIV-1). CCL4 is the most potent chemoattractant of a CD4+CD25+ T cell population, which is a characteristic phenotype of regulatory T cells. Depletion of either regulatory T cells or CCL4 results in a deregulated humoral response, which culminates in the production of autoantibodies. This suggests that the recruitment of regulatory T cells to B cells and antigen-presenting cells (APCs) by CCL4 plays a central role in the normal initiation of T cell and humoral responses, and failure to do this leads to autoimmune activation. | Additional information: Clone REA511 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | ACT-2, LAG-1, HC21, MIP-1-beta, PAT 744, Protein H400, SIS-gamma |
| Gene, Accession # | Gene ID: 6351 |
| Catalog # | 130-129-199 |
| Price | $385 |
| Order / More Info | CCL4 (MIP-1β), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Bystry, R. S. et al. (2001) B cells and professional APCs recruit regulatory T cells via CCL4. Nat Immunol 2 (12): 1126-1132. | Guan, E. et al. (2002) Natural truncation of the chemokine MIP-1 beta /CCL4 affects receptor specificity but not anti-HIV-1 activity. J. Biol. Chem. 277 (35): 32348-32352. | Baixeras, E. et al. (1990) Cloning and expression of a lymphocyte activation gene (LAG-1). Mol. Immunol. 27 (11): 1091-1102. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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