CLA, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CLA, Human |
| Clone | REA1101 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | PerCP-Vio 700 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CLA Antibody, anti-human, PerCP-Vio® 700, REAfinity™. Clone REA1101 recognizes the cutaneous lymphocyte-associated antigen (CLA), a specialized glycoform of P-selectin glycoprotein ligand-1 (PSGL-1). It serves as a ligand for selectins, including CD62E (ELAM-1) and CD62L (LECAM-1). CLA is a unique skin-homing receptor and is predominantly found on a minor subset of human T cells that infiltrate the skin. This post-translational modification of PSGL-1 is thought to serve as a mechanism to regulate tissue-specific homing of CD4+ and CD8+ memory/effector T cells from peripheral blood to the skin, which plays an essential role during many inflammatory and certain malignant skin diseases. In peripheral blood, CLA is not only found on skin-homing memory/effector T cells, but is also found to be expressed on memory/effector B cells, NK cells, blood dendritic cells, and on monocytes. CLA is furthermore found on Langerhans cells in the skin. | Additional information: Clone REA1101 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | SELPLG, CD162, PSGL-1, PSGL1 |
| Gene, Accession # | Gene ID: 6404 |
| Catalog # | 130-119-049 |
| Price | $370 |
| Order / More Info | CLA, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Santamaria Babi, L. F. et al. (1995) Migration of skin-homing T cells across cytokine-activated human endothelial cell layers involves interaction of the cutaneous lymphocyte-associated antigen (CLA), the very late antigen-4 (VLA-4), and the lymphocyte function-associated antigen-1 (LFA-1). J Immunol 154: 1543-1550. | Fuhlbrigge, R. C. et al. (1997) Cutaneous lymphocyte antigen is a specialized form of PSGL-1 expressed on skin-homing T cells. Nature 389: 978-981. | Yoshino, T. et al. (1999) Cutaneous lymphocyte antigen is expressed on memory/effector B cells in the peripheral blood and monocytoid B cells in the lymphoid tissues. Cell. Immunol. 197: 39-45. | Takahashi, R. et al. (2003) In vitro differentiation from naive to mature E-selectin binding CD4 T cells: acquisition of skin-homing properties occurs independently of cutaneous lymphocyte antigen expression. J Immunol 171: 5769-5777. | Bos, J. D. et al. (1993) Skin-homing T lymphocytes: detection of cutaneous lymphocyte-associated antigen (CLA) by HECA.452 in normal human skin. Arch. Dermatol. Res. 285 (179): 179-183. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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