CD244.2, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD244.2, Mouse |
| Clone | REA388 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | Vio Bright FITC conjugate |
| Size | 9 µg in 300 µL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD244.2 Antibody, anti-mouse, Vio® Bright FITC, REAfinity™. Clone REA388 recognizes an alloantigen of the mouse CD244 antigen, a Single-pass type I membrane protein also known as 2B4. CD244 is a receptor belonging to the CD2 subfamily of the Ig superfamily and is involved in non-MHC dependent cytotoxicity. Expression of CD244 is found on all NK cells, γδ T cells, basophils, and monocytes as well as a subset of memory-phenotype CD8+ αβ T cells. The ligand of CD244 is CD48, which is expressed on all hematopoietic cells. CD244 is primarily involved in inhibiting NK cell functions. In inbred mice, at least two splice variants exist that differ in the length of the cytoplasmic domain. The long form functions in an inhibitory manner, while the short form functions in an activating manner. Clone REA388 reacts with CD244.2, the CD244 allloantigen which is expressed on C57BL/6 and C58/J mice, but not in Balb/c mice. | Additional information: Clone REA388 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | CD244, 2B4, C9.1, Ly90, NAIL, NKR2B4, Nmrk, SLAMF4, 2B4 B6 Alloantigen |
| Gene, Accession # | Gene ID: 18106 |
| Catalog # | 130-106-041 |
| Price | $90 |
| Order / More Info | CD244.2, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Mathew, P. A. et al. (1993) Cloning and characterization of the 2B4 gene encoding a molecule associated with non-MHC-restricted killing mediated by activated natural killer cells and T cells. J Immunol 151 (10): 5328-5337. | Kumaresan, P. R. et al. (2000) Polymorphism in the 2B4 gene of inbred mouse strains. Immunogenetics 51 (8-9): 758-761. | McNerney, M. E. et al. (2005) 2B4 (CD244) is a non-MHC binding receptor with multiple functions on natural killer cells and CD8+ T cells. Mol. Immunol. 42 (4): 489 -494. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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