HLA-A2, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | HLA-A2, Human |
| Clone | REA517 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | fluorescein (FITC) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | HLA-A2 Antibody, anti-human, FITC, REAfinity™. Clone REA517 recognizes the class I human leukocyte antigen A2 (HLA-A2). Expressed on the surface of most nucleated cells, class I molecules are heterodimeric molecules and consist of a type I integral membrane α heavy chain and a soluble β2 microglobulin protein. The extracellular region of the heavy chain further consists of three domains, one of which comprises the peptide binding groove. Antigens binding to class I molecules are 8-10 amino acids long and play an important role in recognition of virus infected and malignant cells by cytotoxic T lymphocytes (CTLs). In addition, class I molecules interact with NK cell receptors to modulate the activity of NK cells. | Additional information: Clone REA517 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | MHC class I HLA-A2 |
| Gene, Accession # | Gene ID: 3105 |
| Catalog # | 130-118-969 |
| Price | $275 |
| Order / More Info | HLA-A2, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Bjorkman, P. J. et al. (1987) Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329 (6139): 506-512. | Hewitt, E. W. et al. (2003) The MHC class I antigen presentation pathway: strategies for viral immune evasion. Immunology 110 (2): 163-169. | Smith, S. N. et al. (2013) Plasticity in the contribution of T cell receptor variable region residues to binding of peptide-HLA-A2 complexes. J. Mol. Biol. 425 (22): 4496-4507. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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