CD95 (FAS), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD95 (FAS), Mouse |
| Clone | REA453 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 9 µg in 300 µL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD95 (FAS) Antibody, anti-mouse, Biotin, REAfinity™. Clone REA453 recognizes the mouse CD95 antigen, a single-pass type I membrane protein which is also known as FAS or Apo-1. CD95 is a member of the tumor necrosis factor receptor superfamily and is found on the surface of many normal and neoplastically transformed cells. It is an apoptosis-inducing death receptor that regulates tissue homeostasis mainly in the immune system through induction of apoptosis by binding of its ligand CD95L (FASL/Apo-1L). CD95 and CD95L are up-regulated on lymphocytes upon activation and are known to play a key role in the regulation of an inflammatory response. CD95 also plays an apoptosis-independent role in non-immune cells and it has been implicated in cancer cell growth, migration, and tumor progression. During cancer progression CD95 is frequently down regulated or cells are rendered apoptosis resistant raising the possibility that loss of CD95 is part of a mechanism for tumor evasion. | Additional information: Clone REA453 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | FAS, APO-1, Apt1, Tnfrsf6, TNFR6, Tnfrsf6, lpr |
| Gene, Accession # | Gene ID: 14102 |
| Catalog # | 130-106-969 |
| Price | $31 |
| Order / More Info | CD95 (FAS), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Watanabe-Fukunaga, R. et al. (1992) The cDNA structure, expression, and chromosomal assignment of the mouse Fas antigen. J Immunol 148 (4): 1274-1279. | Chen, L. et al. (2010) CD95 promotes tumour growth. Nature 465 (7297): 492-496. | Hadji, A. et al. (2014) Death induced by CD95 or CD95 ligand elimination. Cell Rep 7 (1): 208-222. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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