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Antigenic Specificity | CD301 (CLEC10A), Human |
Clone | REA586 |
Host Species | Recombinant Human |
Reactive Species | human |
Isotype | IgG1 |
Format | allophycocyanin (APC) conjugate |
Size | 30 tests in 300 µL |
Concentration | 1:11 |
Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CD301 (CLEC10A) Antibody, anti-human, APC, REAfinity™. Clone REA586 recognizes the human CD301 (CLEC10A) antigen, which is a 40 kDa type II transmembrane glycoprotein expressed by immature DCs and activated macrophages. CD301 is a member of the C-type lectin/C-type lectinl-ike domain (CTL/CTLD) superfamily which plays a role in cell adhesion, cell-cell signaling, glycoprotein turnover, inflammation, and immune response. CD301 binds in a calcium-dependent manner to terminal galactose and N-acetylgalactosamine units, linked to serine or threonine. These moieties are known as Tn-Ag which are expressed in a variety of carcinoma cells. | Additional information: Clone REA586 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | Clec10a, C-type lectin superfamily member 14, Macrophage lectin 2, MGL |
Gene, Accession # | Gene ID: 10462 |
Catalog # | 130-109-642 |
Price | $142 |
Order / More Info | CD301 (CLEC10A), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Suzuki, N. et al. (1996) Molecular cloning and expression of cDNA encoding human macrophage C-type lectin. Its unique carbohydrate binding specificity for Tn antigen. J Immunol 156 (1): 128-135. | Napoletano, C. et al. (2012) Targeting of macrophage galactose-type C-type lectin (MGL) induces DC signaling and activation. Eur. J. Immunol. 42 (4): 936-945. |