CD159a (NKG2A), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD159a (NKG2A), Human |
| Clone | REA110 |
| Host Species | Recombinant Human |
| Reactive Species | human, nonhuman primate |
| Isotype | IgG1 |
| Format | Vio Bright FITC conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD159a (NKG2A) Antibody, anti-human, Vio® Bright FITC, REAfinity™. Clone REA110 recognizes CD159a, an inhibitory natural killer (NK) cell receptor. CD159a forms heterodimer with CD94 and contains a C-type lectin ectodomain. Inhibitory signal is transmitted by the heterodimer via immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and upon ligand engagement, ITIMs are phosphorylated and transmit signal through docking of various tyrosine phosphatases. CD159a/CD94 binds non-classical MHC class I protein, HLA-E. Expression of CD159a is found mainly on NK cells and on subsets of CD8+ cells. | Additional information: Clone REA110 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | KLRC1, CD159a, NKG2, NKG2A |
| Gene, Accession # | Gene ID: 3821 |
| Catalog # | 130-114-094 |
| Price | $162 |
| Order / More Info | CD159a (NKG2A), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Rueda, C. et al. (2016) Lipopolysaccharide-induced chorioamnionitis promotes IL-1-dependent inflammatory FOXP3+ CD4+ T cells in the fetal rhesus macaque. J Immunol 196 (9): 3706-3715. | Boyington, J. C. et al. (1999) Structure of CD94 reveals a novel C-type lectin fold: implications for the NK cell-associated CD94/NKG2 receptors. Immunity 10 (1): 75-82. | Sullivan, L. C. et al. (2007) The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition. Immunity 27 (6): 900-911. | Reeves R. K. et al. (2015) Antigen-specific NK cell memory in rhesus macaques. Nat Immunol 16: 927-932. | Veluchamy, J. P. et al. (2017) High-efficiency lysis of cervical cancer by allogeneic NK cells derived from umbilical cord progenitors is independent of HLA status. Cancer Immunol. Immunother. 66: 51-61. | Wolpert, F. et al. (2015) Interferon-β modulates the innate immune response against glioblastoma initiating cells. PLoS One 10 (10): e0139603. | Borrego, F. et al. (2006) The CD94/NKG2 family of receptors: from molecules and cells to clinical relevance. Immunol. Res. 35 (3): 263-278. | Croci, S. et al. (2018) Higher frequencies of lymphocytes expressing the natural killer group 2D receptor in patients with Behcet disease. Front Immunol 9: 2157. | Jacomet, F. et al. (2017) The hypothesis of the human iNKT/innate CD8+ T-cell axis applied to cancer: evidence for a deficiency in chronic myeloid leukemia. Front Immunol 7: 688. | Mahaweni, N. et al. (2018) NKG2A expression is not per se detrimental for the anti-multiple myeloma activity of activated natural killer cells in an in vitro system mimicking the tumor microenvironment. Front Immunol 9: 1415. | Rechtien, A. et al. (2017) Systems vaccinology identifies an early innate immune signature as a correlate of antibody responses to the Ebola vaccine rVSV-ZEBOV. Cell Rep 20 (9): 2251-2261. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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