p53, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | p53, Human |
| Clone | REAL658 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | n/a |
| Format | phycoerythrin (PE) conjugate |
| Size | 200 µL |
| Concentration | n/a |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | p53 Antibody, anti-human, PE, REAdye_lease™. Clone REAL658 is an antibody fragment derived from the full p53 antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity. | Clone REAL658 recognizes the human cellular tumor antigen p53. The p53 protein is an important regulator of cell growth and, thus, functions as a tumor suppressor in many tumor types. The p53 tumor suppressor gene is altered or deleted in most solid human tumors. It is tightly regulated and plays a critical role in the cellular response to environmental stress. Upon a cell's exposure to stress, such as hypoxia or genomic damage, the p53 protein is expressed at high levels and is post-translationally modified. These modifications, which include phosphorylation, acetylation, and glycosylation occur rapidly and lead to the activation of p53, resulting in either G1 growth arrest or programmed cell death. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). |
| Immunogen | n/a |
| Other Names | BCC7, LFS1, P53, TP53 |
| Gene, Accession # | n/a |
| Catalog # | 130-124-178 |
| Price | $460 |
| Order / More Info | p53, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Zakut-Houri, R. et al. (1985) Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. EMBO J. 4 (5): 1251-1255. | Lamb, P. et al. (1986) Characterization of the human p53 gene. Mol. Cell. Biol. 6 (5): 1379-1385. | Stiewe, T. (2007) The p53 family in differentiation and tumorigenesis. Nat. Rev. Cancer 7 (3): 165-168. | Surget, S. et al. (2013) Uncovering the role of p53 splice variants in human malignancy: a clinical perspective. Onco Targets Ther. 7: 57-68. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
Profile of MILTENYI BIOTEC B.V. & Co. KG