TCR Vβ21.3, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | TCR Vβ21.3, Human |
| Clone | REA894 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TCR Vβ21.3 Antibody, anti-human, PE, REAfinity™. Clone REA894 recognizes the human β 21.3 subunit of the αβ T cell receptor (TCR Vβ21.3). The TCR is a disulfide-linked membrane-anchored heterodimeric protein associated with the CD3 antigen. The α and β TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. TCR Vβ21.3 is a variant of the TCR β chain. αβ T cells express a diverse αβ TCR repertoire that specifically co-recognizes self or foreign antigen bound to antigen-presenting molecules, which thereby leads to T cell-mediated immunity. For example, the TCR can directly bind to peptide fragments, riboflavin precursors, and lipid antigens that are presented by major histocompatibility complex (MHC) molecules, MR1 and CD1, respectively. In each case, the antigen sits within the antigen-binding cleft, whereupon the TCR recognizes a composite surface formed by the antigen-presenting molecule and surface-exposed regions of the antigen itself. This co-recognition paradigm is a central tenet of αβ T cell-mediated immunity and underpins MHC restriction. | Additional information: Clone REA894 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | TCR Vbeta21.3, TCR V beta 21.3, TCR Vb21.3 |
| Gene, Accession # | Gene ID: 28581 |
| Catalog # | 130-114-838 |
| Price | $315 |
| Order / More Info | TCR Vβ21.3, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Born, W. et al. (1985) Rearrangement of T-cell receptor beta-chain genes during T-cell development. Proc. Natl. Acad. Sci. U.S.A. 82 (9): 2925-2929. | Leiden, J. M. et al. (1986) Generation of diversity of the beta chain of the human T-lymphocyte receptor for antigen. Proc. Natl. Acad. Sci. U.S.A. 83 (12): 4456-4460. | Wei, S. et al. (1994) The extent of the human germline T-cell receptor V beta gene segment repertoire. Immunogenetics 40 (1): 27-36. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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