Granzyme B, Human/Mouse/Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Granzyme B, Human/Mouse/Rat |
| Clone | REA226 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse, rat |
| Isotype | IgG1 |
| Format | Vio B515 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Granzyme B Antibody, anti-human/mouse/rat, Vio® B515, REAfinity™. Clone REA226 recognizes granzyme B, a 32 kDa member of serine protease family, which is involved in cell lysis mediated by cytotoxic T lymphocytes (CTLs) and NK cells. Also known as granule enzymes, granzymes comprise majority of the mass of cytolytic granules in cytotoxic T lymphocytes (CTLs) and NK cells. Granzyme B is one of the five granzymes expressed by humans. NK cells and γδ T cells express granzymes constitutively, whereas expression in T lymphocytes is stimulation dependent. Main function attributed to granzymes is to indue apoptotic death of infected and transformed cells, where granzyme B enters into the target cell in a perforin dependent manner and via cation-independent mannose-6-phosphate receptor (CI-MPR). Granzyme B cleaves cellular substrates such as procaspase-3 and Bid, which then initiate pathways involved in apoptotic cell death. Granzyme B is suggested to be the only mammalian serine protease that prefers acidic side chains. | Additional information: Clone REA226 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | GZMB, CCPI, CGL-1, CSP-B, CTLA-1, CTSGL1, HLP, SECT, Granzyme 2 |
| Gene, Accession # | Gene ID: 3002, 14939, 171528 |
| Catalog # | 130-130-543 |
| Price | $385 |
| Order / More Info | Granzyme B, Human/Mouse/Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Grossman, W. J. et al. (2004) Differential expression of granzymes A and B in human cytotoxic lymphocyte subsets and T regulatory cells. Blood 104: 2840-2848. | Mullbacher, A. et al. (1999) Granzymes are the essential downstream effector molecules for the control of primary virus infections by cytolytic leukocytes. Proc. Natl. Acad. Sci. U.S.A. 96 (13): 13950 -13955. | Trapani, J. A. (2001) Granzymes: a family of lymphocyte granule serine proteases. Genome Biol. 2 (12): 3014.1-3014.7. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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