CD268, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD268, Mouse |
| Clone | 7H22-E16 |
| Host Species | Rat |
| Reactive Species | mouse |
| Isotype | IgG1κ |
| Format | PE-Vio 770 conjugate |
| Size | 9 µg in 300 µL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD268 Antibody, anti-mouse, PE-Vio® 770. Clone 7H22-E16 reacts with CD268, also known as B cell activation factor receptor (BAFF-R), a type III transmembrane TNF receptor family member. CD268 is expressed at high levels on resting B cells, at lower levels on activated B cells, and on a small subset of activated/memory T cells. BAFF, also known as BLys, mediates costimulatory responses in peripheral B and T cells. BAFF is a key regulator for B cell differentiation as well as survival and activation of peripheral B cell populations. Accordingly, CD268 appears to be particularly involved in the regulation of normal B cell survival and maturation, but also in the pathophysiology of aggressive B cell malignancies and autoimmune diseases. |
| Immunogen | n/a |
| Other Names | TNFRSF13c, BR3, BAFFR, Bcmd, Bcmd-1, Lvis22 |
| Gene, Accession # | Gene ID: 72049 |
| Catalog # | 130-105-215 |
| Price | $57 |
| Order / More Info | CD268, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Ng, L. G. et al. (2004) B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J Immunol 173 (2): 807-817. | Thompson, J. S. et al. (2001) BAFF-R, a newly identified TNF receptor that specifically interacts with BAFF. Science 293 (5537): 2108-2111. | Ng, L. G. et al. (2006) BAFF costimulation of Toll-like receptor-activated B-1 cells. Eur. J. Immunol. 36 (7): 1837-1846. | Yan, M. et al. (2001) Identification of a novel receptor for B lymphocyte stimulator that is mutated in a mouse strain with severe B cell deficiency. Curr. Biol. 11 (19): 1547-1552. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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