TCR Vγ9, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | TCR Vγ9, Human |
| Clone | REA470 |
| Host Species | Recombinant Human |
| Reactive Species | human, nonhuman primate |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TCR Vγ9 Antibody, anti-human, APC, REAfinity™. Clone REA470 recognizes the human variable gamma 9 subunit of the γ/δ T cell receptor (TCR Vγ9). The T cell receptor is a heterodimeric glycoprotein associated with the CD3 antigen. The γ and δ TCR chains are composed of constant and variable regions, each encoded by distinct gene segments. γδ T cells represent unconventional lymphocytes that share characteristics of natural killer (NK) cells and T cells and often express regulatory NK receptors, thereby linking innate and adaptive immunity. Upon cross-linking CD94/NKG2A, antigenic activation of γδ T cells is down-modulated by inhibiting cell proliferation, cytokine production, and cytotoxicity. γδ T cells can detect target cells with patterns of MHC class I expression altered as a result of tumor transformation or viral infection, thus endowing them with a role in immunosurveillance originally attributed to NK cells only. Vγ9/Vδ2 T cells comprise the majority of peripheral human γδ T cells and are capable of responding to the microbial metabolite HMB-PP. | Additional information: Clone REA470 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | n/a |
| Gene, Accession # | Gene ID: 6983 |
| Catalog # | 130-124-042 |
| Price | $140 |
| Order / More Info | TCR Vγ9, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Eberl, M. et al. (2005) Human Vgamma9/Vdelta2 effector memory T cells express the killer cell lectin-like receptor G1 (KLRG1). J. Leukoc. Biol. 77 (1): 67-70. | Karunakaran, M. M. et al. (2014) Vγ9 and Vδ2 T cell antigen receptor genes and butyrophilin 3 (BTN3) emerged with placental mammals and are concomitantly preserved in selected species like alpaca (Vicugna pacos). Immunogenetics 66 (4): 243-254. | Par, G. et al. (2002) Decrease in CD3-negative-CD8dim+ and Vdelta2/Vgamma9 TcR+ peripheral blood lymphocyte counts, low perforin expression and the impairment of natural killer cell activity is associated with chronic hepatitis C virus infection. J. Hepatol. 37 (4): 514-522. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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