S100B, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | S100B, Human/Mouse |
| Clone | REAL1328 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | phycoerythrin (PE) conjugate |
| Size | 200 µL |
| Concentration | n/a |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | S100B Antibody, anti-human/mouse, PE, REAdye_lease™. Clone REAL1328 is an antibody fragment derived from the full S100B antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity. | Clone REAL1328 recognizes the human and mouse S100B protein which controls the activation of Glial fibrillary acidic protein (GFAP), polymerization of tubulin and DNA repair. S100B is a neurotrophic factor and neuronal survival protein and is involved in neurite extension, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. It is expressed in mature astrocytes of the brain, but also found in a variety of other cell types such as T lymphocytes, monocytes, and platelets. S100B is used as a biomarker for neurological disorders: acute brain injury, neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, multiple sclerosis), congenital/perinatal disorders (Down syndrome, spinocerebellar ataxia-1) and psychiatric disorders (schizophrenia, mood disorders). | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). | |
| Immunogen | n/a |
| Other Names | S100-B, S-100 protein beta chain, S-100 protein subunit beta, S100 calcium-binding protein B |
| Gene, Accession # | n/a |
| Catalog # | 130-130-619 |
| Price | $454 |
| Order / More Info | S100B, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Michetti , F. et al. (2019) The S100B story: from biomarker to active factor in neural injury. J Neurochem 148 (2): 168-187. | Langeh, U. et al. (2021) Targeting S100B Protein as a Surrogate Biomarker and its Role in Various Neurological Disorders. Curr Neuropharmacol. 19 (2): 265-277. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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