HLA-E, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | HLA-E, Human |
| Clone | REA1031 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio Bright V423 conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | HLA-E Antibody, anti-human, Vio® Bright V423, REAfinity™. Clone REA1031 recognizes the human HLA-E protein, a member of the human leukocyte antigen family. HLA-E is a non-classical MHC molecule (MHC-Ib) with limited polymorphisms, which is expressed on the cell surface in a heterodimeric complex with β2-microglobulin. HLA-E is ubiquitously expressed and has a specialized role in NK cell recognition. It binds a restricted set of peptides, e.g., derived from other class I leader sequences. The complex is recognized by NKG2A on natural killer (NK) cells. This recognition protects the HLA-E-expressing cell from NK cell killing. Recently HLA-E recognition by a specialised subset of CD8 T cells has been implicated in pathogen recognition as well as autoimmunity. | Additional information: Clone REA1031 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | QA1, EA1.2, EA2.1, HLA-6.2, MHC, HLA-E |
| Gene, Accession # | Gene ID: 3133 |
| Catalog # | 130-128-285 |
| Price | $208 |
| Order / More Info | HLA-E, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Lu, L. et al. (2008) Generation and regulation of CD8+ regulatory T cells. Cell. Mol. Immunol. 5 (6): 401-406. | Jiang, H. et al. (2010) HLA-E-restricted regulatory CD8+ T cells are involved in development and control of human autoimmune type 1 diabetes. J. Clin. Invest. 120 (10): 3641-3650. | Pietra, G. et al. (2010) The emerging role of HLA-E-restricted CD8+ T lymphocytes in the adaptive immune response to pathogens and tumors. J. Biomed. Biotechnol.: 907092. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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