CD366 (TIM-3), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD366 (TIM-3), Human |
| Clone | REA635 |
| Host Species | Recombinant Human |
| Reactive Species | human, nonhuman primate |
| Isotype | IgG1 |
| Format | Vio Bright FITC conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD366 (TIM-3) Antibody, anti-human, Vio® Bright FITC, REAfinity™. Clone REA635 recognizes the human CD366 antigen, a single-pass type I membrane protein, which is also known as T cell immunoglobulin and mucin domain containing protein-3 (TIM-3) or Hepatitis A virus cellular receptor 2 (HAVcr-2). CD366 is expressed on activated T cells, especially T?1 cells, monocytes, macrophages, and dendritic cells. It is an activation-induced inhibitory molecule involved in tolerance and shown to induce T cell exhaustion in chronic viral infection and cancers. CD366 has been proposed to inhibit T?1-mediated immune responses and regulates T?1 and T?17 cytokine secretion. The interaction of CD366 and its ligand galectin-9 induces apoptosis of T?1 cells. | Additional information: Clone REA635 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | HAVcr-2, TIMD-3 |
| Gene, Accession # | Gene ID: 84868 |
| Catalog # | 130-124-442 |
| Price | $360 |
| Order / More Info | CD366 (TIM-3), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Monney, L. et al. (2002) T?1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease. Nature 415: 536-541. | Zhu, C. et al. (2005) The Tim-3 ligand galectin-9 negatively regulates T helper type 1 immunity. Nat Immunol 6 (12): 1245-1252. | Hastings, W. D. et al. (2009) TIM-3 is expressed on activated human CD4+ T cells and regulates T?1 and T?17 cytokines. Eur. J. Immunol. 39 (9): 2492-2501. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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