Syk pY348, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Syk pY348, Human |
| Clone | REA681 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 tests in 300 µL |
| Concentration | 1:11 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Syk pY348 Antibody, anti-human, APC, REAfinity™. Clone REA681 recognizes Syk protein phosphorylated at tyrosine 348. Syk is a 72 kDa non-receptor tyrosine kinase cytoplasmic protein. Syk belongs to the SYK/ZAP 70 family of tyrosine protein kinases and is mainly expressed in hematopoietic cells. Activated immunoreceptors, phosphorylated at ITAM motifs recruit Syk from the cytoplasm to the signalosome complex at the perimembrane location. Syk, upon binding of SH2 domains to immunoreceptor ITAM is activated and undergoes autophosphorylation and phosphorylation by SRC kinases. Activated Syk catalyzes tyrosine phosphorylation of multiple downstream proteins which regulate signaling pathways such AKT, MAP kinase, and NF-κB. A wide variety of cellular and physiological functions such as cell activation and differentiation are regulated by Syk. Phosphorylation at Tyr-348 creates a binding site for VAV1. | Additional information: Clone REA681 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Tyrosine-protein kinase SYK |
| Gene, Accession # | Gene ID: 6850 |
| Catalog # | 130-110-401 |
| Price | $142 |
| Order / More Info | Syk pY348, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Kurosaki, T. et al. (1995) Role of the Syk autophosphorylation site and SH2 domains in B cell antigen receptor signaling. J. Exp. Med. 182 (6): 1815-1823. | Sada, K. et al. (2001) Structure and function of Syk protein-tyrosine kinase. J. Biochem. 130: 177-186. | Siraganian, R. P. et al. (2002) Protein tyrosine kinase Syk in mast cell signaling. Mol. Immunol. 38 (16-18): 1229-1233. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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