TIGIT, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | TIGIT, Human |
| Clone | REA1004 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | Vio Bright V423 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | TIGIT Antibody, anti-human, Vio® Bright V423, REAfinity™. Clone REA1004 recognizes the human T cell immunoglobulin and ITIM domain (TIGIT) antigen, a protein containing an immunoglobulin variable (IgV) domain, a transmembrane domain, and an immunoreceptor tyrosine-based inhibitory motif (ITIM). TIGIT is expressed on T cells, including Treg cells and memory subsets, as well as on natural killer (NK) cells. The poliovirus receptor (PVR; also called NECL5 or CD155) is a high-affinity coreceptor for TIGIT that is highly expressed on dendritic cells (DCs), fibroblasts, endothelial cells, and some tumor cells. The interaction of TIGIT with PVR on DCs leads to the down-regulation of pro-inflammatory cytokine secretion and the induction of interleukin 10 (IL-10) production in DCs, exerting an inhibitory effect on T cell activation. | Additional information: Clone REA1004 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | VSIG9, Vstm3, WUCAM |
| Gene, Accession # | Gene ID: 201633 |
| Catalog # | 130-128-190 |
| Price | $500 |
| Order / More Info | TIGIT, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Yu, X. et al. (2009) The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells. Nat Immunol 10 (1): 48-57. | Levin, S. D. et al. (2011) Vstm3 is a member of the CD28 family and an important modulator of T-cell function. Eur. J. Immunol. 41 (4): 902-915. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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