CD155, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD155, Human |
| Clone | REA1081 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | PE-Vio 770 conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD155 Antibody, anti-human, PE-Vio® 770, REAfinity™. Clone REA1081 recognizes the human CD155 antigen, a single-pass type I membrane protein also known as poliovirus receptor (PVR) or nectin-like protein 5 (NECL-5). CD155 is composed of two Ig-like C2-type domains and one Ig-like V-type domain that is necessary for poliovirus binding and uptake. Four different isotypes (α to δ) exist, originated from alternate splicing of the CD155 mRNA. CD155 is a broadly expressed receptor which is found on, for example, monocytes, a T cell subset, and neurons of the central nervous system. CD155 is also expressed on some CD34+ progenitor cells, particulary on progenitors committed in myeloid differentiation. It can interact with several ligands, such as CD226, TIGIT, CD96, vitronectin, integrin αvβ3, and PDGFR. The functions of CD155 include roles in cell adhesion, neural differentiation, and NK cell effector functions. | Additional information: Clone REA1081 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | PVR, PVS, NECL-5, TAGE4 |
| Gene, Accession # | Gene ID: 5817 |
| Catalog # | 130-119-001 |
| Price | $365 |
| Order / More Info | CD155, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Mendelsohn, C. L. et al. (1989) Cellular receptor for poliovirus: molecular cloning, nucleotide sequence, and expression of a new member of the immunoglobulin superfamily. Cell 56 (5): 855 -865. | Lozano, E. et al. (2013) The CD226/CD155 interaction regulates the proinflammatory (T?1/T?17)/anti-inflammatory (T?2) balance in humans. J Immunol 191 (7): 3673-3680. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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