CD172a (SIRPα), Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD172a (SIRPα), Rat |
| Clone | REA490 |
| Host Species | Recombinant Human |
| Reactive Species | rat |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 9 µg in 300 µL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD172a (SIRPα) Antibody, anti-rat, PE, REAfinity™. Clone REA490 recognizes the rat antigen CD172a, a 75-110 kDa glycosylated receptor-like protein, which is also known as SIRPα or SHPS-1. It binds to its ligand CD47, which inhibits cytokine production by mature dendritic cells (DCs) and avoids maturation of immature DCs. SHPS-1 plays a role in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors, or insulin and mediates negative regulation of phagocytosis, mast cell, and DC activation. CD172a is expressed by neurons and myeloid cells, such as monocytes, macrophages, granulocytes, and DCs. | Additional information: Clone REA490 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Sirp, Bit, Ptpns1, Shps1, Mfr, SIRPα |
| Gene, Accession # | Gene ID: 25528 |
| Catalog # | 130-107-747 |
| Price | $42 |
| Order / More Info | CD172a (SIRPα), Rat Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Adams, S. et al. (1998) Signal-regulatory protein is selectively expressed by myeloid and neuronal cells. J Immunol 161: 1853-1859. | Takada, T. et al. (1998) Roles of the complex formation of SHPS-1 with SHP-2 in insulin-stimulated mitogen-activated protein kinase activation. J. Biol. Chem. 273 (15): 9234-9242. | Fujioka, Y. et al. (1996) A novel membrane glycoprotein, SHPS-1, that binds the SH2-domain-containing protein tyrosine phosphatase SHP-2 in response to mitogens and cell adhesion. Mol. Cell. Biol. 16 (12): 6887-6899. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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