ZAP70, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | ZAP70, Human |
| Clone | REA814 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | ZAP70 Antibody, anti-human, APC, REAfinity™. Clone REA814 recognizes the human zeta-chain-associated protein kinase 70 (ZAP70). ZAP70 plays an essential role in regulation of the adaptive immune response. It is normally expressed near the surface membrane of T cells and natural killer cells. Zap70 associates with the ζ subunit of the T cell antigen receptor and plays a critical role in T cell-signaling. It regulates both T cell-activation switch on and switch off by modulating TCR expression at the T cell surface. During thymocyte development, ZAP70 promotes survival and cell-cycle progression of developing thymocytes before positive selection. Additionally, the ZAP70-dependent signaling pathway may also contribute to primary B cells formation and activation through the B cell receptor. Recruitment and activation of ZAP70 are transient and are terminated by phosphorylation of negative regulatory tyrosine residues and dephosphorylation of positively acting sites. | Additional information: Clone REA814 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | ZAP-70, SRK |
| Gene, Accession # | Gene ID: 7535 |
| Catalog # | 130-112-338 |
| Price | $142 |
| Order / More Info | ZAP70, Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Chan, A. C. et al. (1992) ZAP-70: a 70 kd protein-tyrosine kinase that associates with the TCR zeta chain. Cell 71 (4): 649-662. | Arpaia, E. et al. (1994) Defective T cell receptor signaling and CD8+ thymic selection in humans lacking zap-70 kinase. Cell 76 (5): 947-958. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
Profile of MILTENYI BIOTEC B.V. & Co. KG