PTK7 (CCK-4), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | PTK7 (CCK-4), Human |
| Clone | 188B |
| Host Species | Mouse |
| Reactive Species | human |
| Isotype | IgG2aκ |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 tests in 60 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | PTK7 (CCK-4) Antibody, anti-human, PE. The Anti-PTK7 (CCK-4) antibody (clone 188B) recognizes human protein tyrosine kinase-7 (PTK7). PTK7, also known as colon carcinoma kinase-4 (CCK-4), is a receptor protein tyrosine kinase (RPTK)-like molecule that contains a catalytically inactive tyrosine kinase domain. PTK7 was identified to be important for neural development as a regulator of planar cell polarity, being required for convergent extension movement and neural tube closure. Using the Anti-PTK7 (CCK-4) antibody, PTK7 expression was recently analyzed on blood and bone marrow cells. PTK7 was shown to be expressed on plasmacytoid dendritic cells, CD141 (BDCA-3)high type-2 myeloid dendritic cells, and CD34+ hematopoietic progenitor cells (HPCs). PTK7 was detected on early (CD34+ CD133+) and late (CD34+ CD133-) HPCs. In tonsils, PTK7 was also found on some T cells. |
| Immunogen | n/a |
| Other Names | CCK-4, CCK4 |
| Gene, Accession # | Gene ID: 5754 |
| Catalog # | 130-122-967 |
| Price | $119 |
| Order / More Info | PTK7 (CCK-4), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Lu, X. et al. (2004) PTK7/CCK-4 is a novel regulator of planar cell polarity in vertebrates. Nature 430: 93-98. | Park, S. K. et al. (1996) Characterization of the human full-length PTK7 cDNA encoding a receptor protein tyrosine kinase-like molecule closely related to chick KLG. J. Biochem. 119 (2): 235-239. | Mossie, K. et al. (1995) Colon carcinoma kinase-4 defines a new subclass of the receptor tyrosine kinase family. Oncogene 11: 2179-2184. | Xiao, Z. et al. (2008) Cell-specific internalization study of an aptamer from whole cell selection. Chemistry 14: 1769-1775. | Katoh, M. and Katoh, M. (2007) Comparative integromics on non-canonical WNT or planar cell polarity signaling molecules: transcriptional mechanism of PTK7 in colorectal cancer and that of SEMA6A in undifferentiated ES cells. Int. J. Mol. Med. 20: 405-409. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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