PIR-A/B, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | PIR-A/B, Mouse |
| Clone | REA472 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | PIR-A/B Antibody, anti-mouse, PE, REAfinity™. Clone REA472 recognizes both isoforms of the mouse paired immunoglobulin-like receptor (PIR-A and PIR-B) antigen, a single-pass type I membrane protein which is also known as leukocyte immunoglobulin-like receptor 3 (LIR-3). Cell surface expression of PIR molecules on myeloid and B lineage cells increase with cellular differentiation and activation. PIR molecules are also expressed on dendritic cells, monocytes/macrophages, and mast cells in varying levels, but not on T cells and NK cells. PIR-A/B is a receptor for class I MHC antigens and down-regulates antigen-induced B cell-activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). | Additional information: Clone REA472 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | 6M21, Ly89, PIRA1, Pir, GP91, LIR-3, LILRB3, PIR-B |
| Gene, Accession # | Gene ID: 18722, 18733 |
| Catalog # | 130-106-961 |
| Price | $66 |
| Order / More Info | PIR-A/B, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Kubagawa, H. et al. (1999) Biochemical nature and cellular distribution of the paired immunoglobulin-like receptors, PIR-A and PIR-B. J. Exp. Med. 189 (2): 309-318. | Blery, M. et al. (1998) The paired Ig-like receptor PIR-B is an inhibitory receptor that recruits the protein-tyrosine phosphatase SHP-1. Proc. Natl. Acad. Sci. U.S.A. 95 (5): 2446-2451. | Kubagawa, H. et al. (1997) A novel pair of immunoglobulin-like receptors expressed by B cells and myeloid cells. Proc. Natl. Acad. Sci. U.S.A. 94 (10): 5261-5266. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
Profile of MILTENYI BIOTEC B.V. & Co. KG