CD137L (4-1BBL), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD137L (4-1BBL), Mouse |
| Clone | REA962 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 150 µg in 1 mL |
| Concentration | 1:50 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD137L (4-1BBL) Antibody, anti-mouse, APC, REAfinity™. Clone REA962 recognizes the mouse CD137L antigen, a single-pass type II membrane protein also known as 4-1BB ligand (4-1BBL) or tumor necrosis factor ligand superfamily member 9 (Tnfsf9). CD137L is expressed on activated antigen-presenting cells and plays an essential role in regulating adaptive immune responses. Its receptor, 4-1BB is an inducible co-stimulatory member of the tumor necrosis factor receptor family expressed on activated CD4 and CD8 T cells. 4-1BB can enhance both the proliferation and the survival of murine CD4 and CD8 T cells. Recent evidence in mouse models suggests that 4-1BB/CD137L interaction plays an important role in the memory CD8 T cell response to viruses. | Additional information: Clone REA962 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | 4-1BB ligand, 4-1BBL, TNFSF9 |
| Gene, Accession # | Gene ID: 21950 |
| Catalog # | 130-116-012 |
| Price | $360 |
| Order / More Info | CD137L (4-1BBL), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Goodwin, R. G. et al. (1993) Molecular cloning of a ligand for the inducible T cell gene 4-1BB: a member of an emerging family of cytokines with homology to tumor necrosis factor. Eur. J. Immunol. 23 (10): 2631-2641. | Wang, C. et al. (2009) Immune regulation by 4-1BB and 4-1BBL: complexities and challenges. Immunol. Rev. 229 (1): 192-215. | Ma, J. et al. (2013) The TNF family member 4-1BBL sustains inflammation by interacting with TLR signaling components during late-phase activation. Sci Signal 6 (295): ra87. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
Profile of MILTENYI BIOTEC B.V. & Co. KG