CD63, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD63, Mouse |
| Clone | REA563 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | Vio Bright FITC conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry, Immunofluorescence, Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD63 Antibody, anti-mouse, Vio® Bright FITC, REAfinity™. Clone REA563 recogizes the mouse CD63 antigen. It belongs to the tetraspanin transmembrane 4 superfamily (TM4SF) of proteins, which are characterized by four membrane spanning domains. Tetraspanins, via various homotypic and heterotypic interactions, regulate the spatial location and trafficking of associated transmembrane partners, eventually regulating and co-ordinating various signaling pathways. Interaction of CD63 with other membrane proteins or adaptors regulates cell activities such as adhesion, migration, and degranulation. CD63 is expressed on monocytes, macrophages, endothelium, fibroblasts, osteoclasts, smooth muscle cells, and activated platelets. | Additional information: Clone REA563 displays negligible binding to Fc receptors |
| Immunogen | n/a |
| Other Names | ME491, Tspan30 |
| Gene, Accession # | Gene ID: 12512 |
| Catalog # | 130-108-897 |
| Price | $187 |
| Order / More Info | CD63, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Kraft, S. et al. (2013) The tetraspanin CD63 is required for efficient IgE-mediated mast cell degranulation and anaphylaxis. J Immunol 191 (6): 2871-2878. | Doyle, E. L. et al. (2011) CD63 is an essential cofactor to leukocyte recruitment by endothelial P-selectin. Blood 118 (15): 4265-4273. | Miyamoto, H. et al. (1994) Molecular cloning of the murine homologue of CD63/ME491 and detection of its strong expression in the kidney and activated macrophages. Biochim. Biophys. Acta 1217 (3): 312-316. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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