Ly-49A/D, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Ly-49A/D, Mouse |
| Clone | REA853 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | phycoerythrin (PE) conjugate |
| Size | 30 µg in 200 µL |
| Concentration | 1:50 |
| Applications | Flow cytometry, Immunofluorescence, MICS (MACSima Imaging Cyclic Staining), Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Ly-49A/D Antibody, anti-mouse, PE, REAfinity™. Clone REA853 recognizes the mouse Ly-49A and Ly-49D antigens belonging to the Ly-49 family. Members of Ly-49 family are homodimeric C-type lectin receptors, recognizing MHC class I molecules as ligands, and include activating and inhibitory receptor molecules. Ly-49A is a 44 kDa type II transmembrane, disulfide-linked homodimer with C-type lectin extracellular domains. Expression of Ly-49A is found on subset of NK and NK T cells. Ly-49D is a prototypic activating member of Ly-49 family and in contrast to inhibitory members, lacks a cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM). A positive signal is initiated by interaction of Ly-49D with immunoreceptor tyrosine-based activating motif (ITAM) containing transmembrane adapter DAP12. | Clone REA853 does not react with BALB/c, DBA/2, AKR, or CBA/J Ly-D49D. | Additional information: Clone REA853 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Ly49A, Ly49D |
| Gene, Accession # | Gene ID: 16627, 16635 |
| Catalog # | 130-112-938 |
| Price | $72 |
| Order / More Info | Ly-49A/D, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Yokoyama, W. M. et al. (1993) The Ly-49 and NKR-P1 gene families encoding lectin-like receptors on natural killer cells: the NK gene complex. Annu. Rev. Immunol. 11: 613-635. | Mason, L. H. et al. (1996) The Ly-49D receptor activates murine natural killer cells. J. Exp. Med. 184: 2119-2128. | Takei, F. et al. (1997) The Ly-49 family: genes, proteins and recognition of class I MHC. Immunol. Rev. 155: 67-77. | Ortaldo, J. R. et al. (1998) The Ly-49 family: regulation of cytotoxicity and cytokine production in murine CD3+ cells. J Immunol 160 (3): 1158-1165. | Ortaldo, J. R. et al. (1999) Ly-49 receptor expression and functional analysis in multiple mouse strains. J. Leukoc. Biol. 66 (3): 512-520. | Hanke, T. et al. (1999) Direct assessment of MHC class I binding by seven Ly49 inhibitory NK cell receptors. Immunity 11 (1): 67-77. | Chung, D. H. et al. (2000) Mapping the ligand of the NK inhibitory receptor Ly49A on living cells. J Immunol 165: 6922-6932. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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