BLNK pY84, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
Search, find, compare suppliers for anti-BLNK pY84, Human/Mouse antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | BLNK pY84, Human/Mouse |
| Clone | REA240 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:10 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | BLNK pY84 Antibody, anti-human/mouse, APC, REAfinity™. Clone REA240 recognizes BLNK protein phosphorylated at tyrosine 84. BLNK is an approximately 50 KDa src homology 2 and 3 domain-containing protein that bears homology to another adaptor molecule called SLP-76 and serves as a central linker/adaptor protein involved in bridging B cell receptor-associated kinase activation with downstream signaling pathways. BLNK is phosphorylated upon BCR stimulation and couples protein tyrosine kinase (PTK) Syk activation to downstream components such as Grb2, Vav, Nck, and phospholipase C (PLC)-γ2. Further, BLNK has been shown to play a role in the activation of all three classes of mitogen-activated protein kinases (MAPKs). Expression of BLNK is found in B cell lineage cells. | Additional information: Clone REA240 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | AGM4, BASH, BLNK-S, SLP65, bca, Ly-57, Lyw-57 |
| Gene, Accession # | Gene ID: 29760, 17060 |
| Catalog # | 130-101-485 |
| Price | $325 |
| Order / More Info | BLNK pY84, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Baba, Y. et al. (2001) BLNK mediates Syk-dependent Btk activation. Proc. Natl. Acad. Sci. U.S.A. 98: 2582-2586. | Wong, J. et al. (2000) Functional complementation of BLNK by SLP-76 and LAT linker proteins. J. Biol. Chem. 275: 33116-33122. | Kabak, S. et al. (2002) The direct recruitment of BLNK to immunoglobulin couples the B-cell antigen receptor to distal signaling pathways. Mol. Cell. Biol. 22: 2524-2535. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
Profile of MILTENYI BIOTEC B.V. & Co. KG
Return to Antibodies