STAT1 pY701, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | STAT1 pY701, Human/Mouse |
| Clone | REA159 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | STAT1 pY701 Antibody, anti-human/mouse, APC, REAfinity™. Clone REA159 recognizes the Y701 phosphorylated form (pY701) of STAT1, a member of signal transducers and activators of transcription (STAT) family. STAT family members play a critical role in activation of signaling pathways in response to the presence of various cytokines and growth factors (interferon (IFN)-α, IFN-γ, EGF, PDGF, and interleukin (IL)-6). In response to binding of IFNs to their respective receptors, STAT1, which is receptor bound, is activated by phosphorylation at the Y701 residue by Janus protein tyrosine kinases (Jaks). Activation of STAT1 is accompanied by its dissociation from the receptor and formation of homodimer and complex with STAT2 and p48 followed by translocation of the homodimer and complex to the nucleus. STAT1 is involved in positive regulation of IFN-stimulated genes, negatively regulates expression of genes for thyrotropin receptor, matrix metalloproteinase 1, 2, 13, etc. and constitutive expression of caspases 1, 2, 3, and LMP2 genes. STAT1 expression is found ubiquitously. | Additional information: Clone REA159 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | CANDF7, IMD31A, IMD31B, IMD31C, ISGF-3, STAT91 |
| Gene, Accession # | Gene ID: 6772, 20846 |
| Catalog # | 130-130-016 |
| Price | $365 |
| Order / More Info | STAT1 pY701, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Gimeno, R. et al. (1996) STAT1 implication in the immune response to superantigens in vivo. J Immunol 156: 1378-1386. | Sikorski, K. et al. (2011) STAT1-mediated signal integration between IFNγ and LPS leads to increased EC and SMC activation and monocyte adhesion. Am. J. Physiol., Cell Physiol. 300: C1337-C1344. | Mowen, K. et al. (1998) Role of the STAT1-SH2 domain and STAT2 in the activation and nuclear translocation of STAT1. J. Biol. Chem. 273: 30073-30076. | ten Hoeve, J. et al. (2002) Identification of a nuclear Stat1 protein tyrosine phosphatase. Mol. Cell. Biol. 16: 5662-5668. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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