CD305 (LAIR-1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG
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|---|---|
| Antigenic Specificity | CD305 (LAIR-1), Human |
| Clone | REA447 |
| Host Species | Recombinant Human |
| Reactive Species | human |
| Isotype | IgG1 |
| Format | biotin conjugate |
| Size | 100 tests in 1 mL |
| Concentration | 1:11 |
| Applications | Flow cytometry, MICS (MACSima Imaging Cyclic Staining), Immunofluorescence, Immunohistochemistry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD305 (LAIR-1) Antibody, anti-human, Biotin, REAfinity™. Clone REA447 recognizes the human CD305 antigen, a single-pass type I membrane protein which is also known as leukocyte-associated immunoglobulin-like receptor 1 (LAIR-1). CD305 contains a single extracellular immunoglobulin-like domain and a cytoplasmic tail containing two immune receptor tyrosine-based inhibitory motifs. It is structurally related to several other inhibitory Ig superfamily members. CD305 is expressed on almost all immune cells, including NK cells, T cells, B cells, monocytes, monocyte-derived dendritic cells, eosinophils, basophils, and mast cells. Besides being expressed on differentiated peripheral blood cells, the receptor is also present on CD34+ hematopoietic progenitor cells and on the majority of thymocytes. Cross-linking of CD305 on human NK cells delivers a potent inhibitory signal that is capable of inhibiting target cell lysis by resting and activated NK cells. Furthermore, CD305 can inhibit the cytotoxic activity of effector T cells upon CD3 cross-linking or antigen stimulation. In primary B cells, CD305 cross-linking leads to decreased BCR-induced calcium mobilization and down-regulation of Ig and cytokine production. | Additional information: Clone REA447 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | hLAIR1, CD305, LAIR-1 |
| Gene, Accession # | Gene ID: 3903 |
| Catalog # | 130-106-804 |
| Price | $262 |
| Order / More Info | CD305 (LAIR-1), Human Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Meyaard, L. et al. (1997) LAIR-1, a novel inhibitory receptor expressed on human mononuclear leukocytes. Immunity 7 (2): 283-290. | Meyaard, L. (2008) The inhibitory collagen receptor LAIR-1 (CD305). J. Leukoc. Biol. 83 (4): 799-803. | Perbellini, O. et al. (2014) Clinical significance of LAIR1 (CD305) as assessed by flow cytometry in a prospective series of patients with chronic lymphocytic leukemia. Haematologica 99 (5): 881-887. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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