CD66a, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | CD66a, Mouse |
| Clone | REA410 |
| Host Species | Recombinant Human |
| Reactive Species | mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 30 µg in 1 mL |
| Concentration | 1:10 |
| Applications | Flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | CD66a Antibody, anti-mouse, APC, REAfinity™. Clone REA410 recognizes the mouse CD66a antigen, a Single-pass type I membrane protein which is also known as Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1). CD66a is an adhesion molecule that is involved in many immune responses associated with infection, inflammation and cancer. In the mouse, CD66a is expressed on the plasma membranes of a variety of cells and tissues like endothelial cells, macrophages, dendritic cells, thymic epithelial cells, B lymphocytes and activated T lymphocytes. CD66a is also the principal receptor for mouse hepatitis virus (MHV). Wild mice have two alleles of the mCeacam1 gene, called mCeacam1a and mCeacam1b. Inbred mouse strains that are homozygous for the isoform Ceacam1a, including BALB/c, C57BL/6 (B6), C3H, and A/J mice, are highly susceptible to infection with strains of MHV. In contrast, the SJL line of inbred mice, which is resistant to death from MHV infection, is homozygous for the Ceacam1b isoform, which is not recognized by clone REA410. | Additional information: Clone REA410 displays negligible binding to Fc receptors. |
| Immunogen | n/a |
| Other Names | Ceacam1, BGP, BGP-1, MHV-R, MHVR1, Bgpd, CEACAM1 |
| Gene, Accession # | Gene ID: 26365 |
| Catalog # | 130-106-210 |
| Price | $89 |
| Order / More Info | CD66a, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Chen, L. et al. (2012) The short isoform of the CEACAM1 receptor in intestinal T cells regulates mucosal immunity and homeostasis via Tfh cell induction. Immunity 37 (5): 930-946. | Mima, J. et al. (2013) Regulation of the epithelial adhesion molecule CEACAM1 is important for palate formation. PLoS One 8 (4): e61653. | Dveksler, G. S. et al. (1993) Several members of the mouse carcinoembryonic antigen-related glycoprotein family are functional receptors for the coronavirus mouse hepatitis virus-A59. J. Virol. 67 (1): 1-8. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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