CD87, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG

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Antigenic SpecificityCD87, Mouse
CloneREA630
Host SpeciesRecombinant Human
Reactive Speciesmouse
IsotypeIgG1
Formatphycoerythrin (PE) conjugate
Size9 µg in 300 µL
Concentration1:10
ApplicationsFlow cytometry
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DescriptionCD87 Antibody, anti-mouse, PE, REAfinity™. Clone REA630 recognizes the mouse CD87 antigen, a key molecule involved in invasive migration of angiogenic endothelium, also known as uPAR. CD87 binds uPA (urokinase plasminogen activator) and thus facilitates the catalytic C domain of the uPA to come in close proximity of membranebound plasminogen. uPA is a serine protease, which converts plasminogen into plasmin which in turn is involved in digestion of various extracellular matrix proteins. CD87 belongs to the Ly6/neurotoxin receptor family and consists of three disulfide-bonded homologous domains, D1, D2, and D3. Function of uPAR is modulated by two inhibitors, PA1 and PA2. CD87 is expressed in angiogenic endothelial cells. | Additional information: Clone REA630 displays negligible binding to Fc receptors.
Immunogenn/a
Other NamesU-PAR, uPAR
Gene, Accession #Gene ID: 18793
Catalog #130-109-897
Price$46
Order / More InfoCD87, Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
Product Specific ReferencesMiljkovic-Licina, M. et al. (2009) Sushi repeat protein X-linked 2, a novel mediator of angiogenesis. FASEB J. 23 (12): 4105-4116. | Lin, L. et al. (2010) Structure-based engineering of species selectivity in the interaction between urokinase and its receptor: implication for preclinical cancer therapy. J. Biol. Chem. 285 (14): 10982-10992. | Suh, T. T. et al. (1994) The murine urokinase-type plasminogen activator receptor gene. J. Biol. Chem. 269 (42): 25992-25998.
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-Straße 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197

macs@miltenyibiotec.de

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