Ki-67, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG
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| Antigenic Specificity | Ki-67, Human/Mouse |
| Clone | REA183 |
| Host Species | Recombinant Human |
| Reactive Species | human, mouse |
| Isotype | IgG1 |
| Format | allophycocyanin (APC) conjugate |
| Size | 100 tests in 200 µL |
| Concentration | 1:50 |
| Applications | Intracellular flow cytometry |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Ki-67 Antibody, anti-human/mouse, APC, REAfinity™. Clone REA183 recognizes the Ki-67 antigen, a nuclear and nucleolar protein, which is strictly associated with cell proliferation. Two Ki-67 isoforms with molecular weight, 395 and 345 kDa are known. Both isoforms contain 16 ``Ki-67 repeat`` sequences, each of which includes a conserved 66 bp ``Ki-67 motif``. Expression of Ki-67 protein is present during all active phases of the cell cycle (G(1), S, G(2), and mitosis), but is absent from resting cells (G(0)). Due to strict association of Ki-67 with proliferating cells, Ki-67 is often used as an indicator of the ``growth fraction`` of a given cell population. The N-terminal portion of Ki-67 contains a forkhead associated (FHA)1 domain, which is involved in interaction with proteins such as Hklp2 and NIFK. | Additional information: Clone REA183 displays negligible binding to Fc receptors. | |
| Immunogen | n/a |
| Other Names | MKI67, KIA, MIB-, MIB-1, PPP1R105, Ki67 |
| Gene, Accession # | Gene ID: 4288 |
| Catalog # | 130-120-416 |
| Price | $325 |
| Order / More Info | Ki-67, Human/Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
| Product Specific References | Verheijen, R. et al. (1989) Ki-67 detects a nuclear matrix-associated proliferation-related antigen. II. Localization in mitotic cells and association with chromosomes. J. Cell. Sci. 92: 531-540. | Takagi, M. et al. (2001) A novel nucleolar protein, NIFK, interacts with the forkhead associated domain of Ki-67 antigen in mitosis. J. Biol. Chem. 276: 25386-25391. | Bhatnagar, N. et al. (2017) Potential role of Vδ2+ γδ T cells in regulation of immune activation in primary HIV infection. Front Immunol 8: . | Campbell, S. et al. (2018) Myeloid cell recruitment versus local proliferation differentiates susceptibility from resistance to filarial infection. Elife 7: . | Schloder, J. et al. (2017) Dimethyl fumarate therapy significantly improves the responsiveness of T cells in Multiple sclerosis patients for immunoregulation by regulatory T cells. Int J Mol Sci 18: E271. | Hyrenius-Wittsten, A. et al. (2018) De novo activating mutations drive clonal evolution and enhance clonal fitness in KMT2A-rearranged leukemia. Nat Commun. 9 (1): 1770. | Jackson-Jones, L. H. et al. (2016) Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation. Nat Commun. 7: 12651. |
MILTENYI BIOTEC B.V. & Co. KG
MILTENYI BIOTEC B.V. & Co. KG
Friedrich-Ebert-StraÃe 68
51429 Bergisch Gladbach GERMANY
P: +49 2204 8306-0
F: +49 2204 85197
macs@miltenyibiotec.de
https://www.miltenyibiotec.com
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