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Antigenic Specificity | MHC Class II (I-Ak), Mouse |
Clone | REA610 |
Host Species | Recombinant Human |
Reactive Species | mouse |
Isotype | IgG1 |
Format | biotin conjugate |
Size | 30 µg in 1 mL |
Concentration | 1:10 |
Applications | Flow cytometry |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | MHC Class II (I-Ak) Antibody, anti-mouse, Biotin, REAfinity™. Clone REA610 recognizes the β chain of the mouse MHC class II alloantigen I-Ak of H-2k bearing mouse strains. It also cross-reacts with the H-2f, H-2r, and H-2s haplotypes, but reactivity to other haplotypes (i.e., b, d, p, and q) has not been observed. It also cross-reacts with splenocytes from nonobese diabetic (NOD) mice, and with lymph node cells of BN, DA, WRA, and WRC rats. MHC class II is expressed on antigen-presenting cells, such as dendritic cells, monocytes, macrophages, B cells in lymphoid and non-lymphoid tissue, thymic epithelial cells, and on subsets of hematopoietic progenitor cells in the bone marrow. | Additional information: Clone REA610 displays negligible binding to Fc receptors. |
Immunogen | n/a |
Other Names | MHC class II IAk, Aβk, A beta K, Aalpha, H-2Aa, H2Aa, I-Aalpha, IAalpha |
Gene, Accession # | Gene ID: 14960 |
Catalog # | 130-109-271 |
Price | $57 |
Order / More Info | MHC Class II (I-Ak), Mouse Antibody from MILTENYI BIOTEC B.V. & Co. KG |
Product Specific References | Bhattacharya, A. et al. (1981) A shared alloantigenic determinant on Ia antigens encoded by the I-A and I-E subregions: evidence for I region gene duplication. J Immunol 127 (6): 2488-2495. | Nelson, C. A. et al. (1996) A negatively charged anchor residue promotes high affinity binding to the MHC class II molecule I-Ak. J Immunol 157 (2): 755-762. | Ting, J. P. et al. (2002) Genetic control of MHC class II expression. Cell 109: 21-33. |